Drug-drug interaction of Linezolid

Linezolid ↔ Phenylpropanolamine

Using phenylpropanolamine together with linezolid can increase your blood pressure.

Linezolid↔ Dextromethorphan

Coadministration of dextromethorphan with linezolid may increase the risk of serotonin syndrome, a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors.

Linezolid ↔ Pseudoephedrine

Using pseudoephedrine together with linezolid can increase your blood pressure

Linezolid↔ Isometheptene mucate

Using isometheptene mucate together with linezolid can increase your blood pressure.

Linezolid↔ Phenylephrine

Using phenylephrine together with linezolid can increase your blood pressure.

Linezolid↔ Tramadol

Using linezolid together with traMADol is not recommended. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm or stiffness, tremor, stomach cramp, nausea, vomiting, and diarrhea.

Linezolid ↔ atomoxetine

Using linezolid together with atomoxetine is not recommended. Combining these medications can cause dangerously high blood pressure and even death. You may use atomoxetine only after you have been off linezolid for at least 14 days.

Linezolid ↔ adalimumab

Using adalimumab together with linezolid may increase the risk of serious infections. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications.

Linezolid ↔ Alfentanil

Using alfentanil together with linezolid can increase the risk of a rare but serious condition called the serotonin syndrome.

Linezolid ↔ Almotriptan

Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome.

Linezolid↔ Amphetamine

Using linezolid together with amphetamine is not recommended. Combining these medications can cause dangerously high blood pressure and even death.

Linezolid↔ Amoxapine

Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome.

Linezolid↔ Benzphetamine

Combining these medications can cause dangerously high blood pressure and even death.

Linezolid↔ Buspirone

Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome.

Linezolid↔ Ergotamine

Using ergotamine together with linezolid can increase the risk of a rare but serious condition called the serotonin syndrome.

Linezolid ↔ Dopamine

Using Dopamine together with linezolid can increase your blood pressure.

Linezolid↔ Fenfluramine

Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome.

Linezolid↔ Levodopa

Combining these medications may lead to dangerous increases in your blood pressure, a condition known as hypertensive crisis. The risk of a stroke may also be increased.

Linezolid ↔ Tryptophan

Using linezolid together with tryptophan can increase the risk of a rare but serious condition called the serotonin syndrome.

Food-drug interaction of Linezolid

While you are taking linezolid, you must not eat or drink certain foods and beverages that are high in tyramine. Eating these foods while you are taking linezolid can raise your blood pressure to dangerous levels. This may cause life threatening symptoms such as severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body). Call your doctor at once if you have any of these symptoms. Foods that are high in tyramine include: air dried meats, aged or fermented meats, sausage or salami, pickled herring, and any spoiled or improperly stored beef, poultry, fish, or liver, red wine, beer from a tap, beer that has not been pasteurize, aged cheeses, including blue, brick, brie, cheddar, parmesan, romano, and swiss, sauerkraut, over the counter supplements or cough and cold medicines that contain tyramine, soy beans, soy sauce, tofu, miso soup, bean curd, fava beans, or yeast extracts (such as Marmite).

Disease-drug interaction of Linezolid

Linezolid ↔ Bone Marrow Suppression

Reversible myelosuppression, including anemia, leukopenia, pancytopenia and thrombocytopenia, has been reported during postmarketing use of linezolid. Therapy with linezolid should be administered cautiously in patients with preexisting blood dyscrasias and in patients receiving concomitant medications that may produce myelosuppression.

Linezolid ↔ Colitis

Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening. Antibiotic therapy can alter the normal flora of the colon and permit overgrowth of Clostridium difficile, whose toxin is believed to be a primary cause of antibiotic-associated colitis.

Linezolid ↔ Carcinoid Syndrome

Linezolid is a weak, reversible, nonselective monoamine oxidase inhibitor (MAOI). Nonspecific MAOIs inhibit the breakdown of pressor amines, including serotonin, and may exacerbate symptoms of the carcinoid syndrome.

Linezolid ↔ Hemodialysis

Linezolid is partially removed by hemodialysis and should be administered after dialysis.

Linezolid ↔ Liver Disease

Linezolid is primarily metabolized by the liver. Therapy with linezolid should be administered cautiously in patients with liver disease.

Linezolid ↔ Maoi Activity

Linezolid is a weak, reversible, nonselective monoamine oxidase inhibitor (MAOI). Nonspecific MAOIs inhibit the breakdown of pressor amines, the accumulation of which can precipitate hypertensive crises.

Linezolid ↔ Renal Dysfunction

Linezolid is primarily metabolized by the liver and subsequently eliminated by the kidney.

Therapy with linezolid should be administered cautiously in patients with renal impairment.