مارس 8, 2016

Gentamicin Drug Interactions

Gentamicin↔ Cefazolin

Gentamicin can sometimes cause kidney damage, and using it with a cephalosporin antibiotic like cefazolin may increase that risk. Signs and symptoms of kidney damage may include nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion

Gentamicin↔ furosemide

Ask your doctor before using gentamicin together with furosemide; this can increase the effects of gentamicin. This can cause damage to the kidneys or hearing loss

Gentamicin↔ pantoprazole

Using pantoprazole together with gentamicin may cause a condition called hypomagnesemia, or low blood magnesium. Drugs known as proton pump inhibitors including pantoprazole can cause hypomagnesemia ,when used for a prolonged period

Gentamicin disease Interactions

(1)Aminoglycosides (Includes Gentamicin) ↔ Dehydration

Adequate hydration is crucial to minimize the risk of oto- and nephrotoxicity associated with the use of aminoglycosides. Dehydration should preferably be corrected prior to initiation of therapy

(2)Aminoglycosides (Includes Gentamicin) ↔ Neuromuscular Blockade

Aminoglycosides can cause dose-related neuromuscular blockade and muscle weakness, particularly in patients with neuromuscular disease or hypocalcemia and in patients receiving general anesthetics, neuromuscular blocking agents, or massive transfusions of citrate-anticoagulated blood. Neomycin is thought to be the most potent neuromuscular blocking agent in the class

(3)Aminoglycosides (Includes Gentamicin) ↔ Ototoxicity

Aminoglycosides can cause eighth cranial nerve damage, resulting in vestibular and/or auditory toxicities. Symptoms include dizziness, nystagmus, vertigo, ataxia, tinnitus, and varying degrees of hearing impairment. Permanent hearing loss may occur, including, rarely, total or partial irreversible bilateral deafness after the drug has been discontinued

(4)Aminoglycosides (Includes Gentamicin) ↔ Renal Dysfunction

Aminoglycosides are potentially oto- and nephrotoxic. Nephrotoxicity is usually evidenced by tubular necrosis; increases in BUN, nonprotein nitrogen, and serum creatinine concentration; decreases in urine specific gravity and creatinine clearance; proteinuria; and cells or casts in the urine



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