Cephalexin Drug Interactions
Cephalexin ↔ metformin
Using cephalexin together with metFORMIN may increase the effects of metFORMIN on lowering blood sugar. This could cause your blood sugar levels to get too low
Cephalexin ↔ ethinyl estradiol
Antibiotics such as cephalexin may reduce the effects of ethinyl estradiol in some women. If you are using ethinyl estradiol for birth control, you may be at increased risk for pregnancy or breakthrough bleeding
Cephalexin ↔ pemetrexed
Cephalexin may increase the blood levels and effects of Pemetrexed. You may be more likely to develop serious side effects such as anemia, bleeding problems, infections, and nerve damage when these medications are used together
Cephalexin ↔ indium oxyquinoline in-111
Treatment with cephalexin can interfere with indium oxyquinoline In-111 test results. Let your doctor know you are on cephalexin if you are scheduled for a indium oxyquinoline In-111 test
Cephalexin↔ probenecid
Probenecid may increase the blood levels of cephalexin. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea and kidney problems
Cephalexin↔ chloramphenicol
Chloramphenicol may diminish the effects of cephalexin in the treatment of certain infections
Cephalexin ↔ balsalazide
Talk to your doctor before using balsalazide together with cephalexin. Antibiotics like cephalexin may reduce the effectiveness of balsalazide when taken orally
Cephalexin ↔ torsemide
Cephalosporin antibiotics like cephalexin can occasionally cause kidney problems, and using it with torsemide may increase that risk. The interaction is more likely to occur when the cephalosporin is given at high dosages by injection into the vein or when it is given to the elderly or individuals with preexisting kidney function impairment
Cephalexin ↔ ethacrynic acid
Cephalosporin antibiotics like cephalexin can occasionally cause kidney problems, and using it with ethacrynic acid may increase that risk. The interaction is more likely to occur when the cephalosporin is given at high dosages by injection into the vein or when it is given to the elderly or individuals with preexisting kidney function impairment
Cephalexin ↔ mycophenolic acid
Cephalexin may decrease the blood levels and effects of mycophenolic acid. You may need a dose adjustment if you have been taking mycophenolic acid and are starting treatment with cephalexin
Cephalexin ↔ typhoid vaccine, live
If you are currently being treated with cephalexin or have been treated within the last 3 days, you should talk to your doctor before receiving typhoid vaccine, live. Antibiotics like cephalexin can reduce the activity of the vaccine. To ensure adequate vaccine response, you should not receive typhoid vaccine, live until at least 3 days after you complete your cephalexin therapy
Cephalexin Disease Interactions
Cephalexin ↔ Colitis
Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening, with an onset of up to two months following cessation of therapy. Antibiotic therapy can alter the normal flora of the colon and permit overgrowth of Clostridium difficile, whose toxin is believed to be a primary cause of antibiotic-associated colitis
Cephalexin ↔ Renal Dysfunction
Most beta-lactam antibiotics are eliminated by the kidney as unchanged drug and, in some cases, also as metabolites. The serum concentrations of beta-lactam antibiotics and their metabolites may be increased and the half-lives prolonged in patients with impaired renal function
Cephalexin ↔ Dialysis
Most cephalosporin antibiotics are removed by hemodialysis. Doses should either be scheduled for administration after dialysis or supplemental doses be given after dialysis. Cefonicid, cefixime,and ceftriaxone are not significantly removed by hemodialysis.