Drug interaction of Amlodipine
Amlodipine ↔ Dolasetron
Talk to your doctor before using dolasetron together with amlodipine. Combining these medications can increase the risk of an irregular heart rhythm that may be serious. You may need a dose adjustment or special tests to safely use both medications
Amlodipine ↔ Simvastatin
Combining these medications may significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death
Amlodipine ↔ Itraconazole
Combining these medications can significantly increase the blood levels and effects of amlodipine. You may be more likely to experience serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure
Amlodipine ↔ Tizanidine
Tizanidine and amlodipine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Multivitamin with minerals
Using amlodipine together with multivitamin with minerals can decrease the effects of amlodipine
Amlodipine ↔ Ibuprofen
The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often
Amlodipine ↔ Hydrocortisone
Hydrocortisone may reduce the effects of amlodipine in lowering blood pressure. The interaction is most likely to occur when hydrocortisone is used for more than a week, since prolonged use can cause sodium and water retention
Amlodipine ↔ Amifostine
Combining these medications may have additive effects in lowering your blood pressure
Amlodipine ↔ Salsalate
The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often
Amlodipine ↔ Aripiprazole
Aripiprazole and amlodipine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Fentanyl
Amlodipine and fentanyl may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ phenobarbital
Phenobarbital may reduce the blood levels and effects of amlodipine
Amlodipine ↔ Ritonavir
Ritonavir may increase the blood levels of amlodipine. You may be more likely to experience serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure
Amlodipine ↔ Acebutolol
Acebutolol and amlodipine may have additive effects in lowering your blood pressure and heart rate. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heartbeat
Amlodipine ↔ parenteral nutrition solution w/electrolytes
Using amlodipine together with parenteral nutrition solution w/electrolytes can decrease the effects of amlodipine
Amlodipine ↔ Codeine
Amlodipine and codeine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Aspirin
The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often
Amlodipine ↔ Butalbital
Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum concentrations and effects of these calcium channel blockers may be significantly decreased
Amlodipine ↔ Magnesium salicylate
The combination may cause your blood pressure to increase
Amlodipine ↔ Calcium carbonate
Using amlodipine together with calcium carbonate can decrease the effects of amlodipine. Talk with your doctor before using amlodipine and calcium carbonate together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications
Amlodipine ↔ Perphenazine
Perphenazine and amlodipine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Amobarbital
Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum concentrations and effects of these calcium channel blockers may be significantly decreased
Amlodipine ↔ Amprenavir
Amprenavir may increase the blood levels of amLODIPine. You may be more likely to experience serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure
Amlodipine ↔ Oxycodone
Amlodipine and oxycodone may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Triamcinolone
Triamcinolone may reduce the effects of amlodipine in lowering blood pressure
Amlodipine ↔ Naproxen
The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often
Amlodipine ↔ Succinylcholine
Using succinylcholine together with amlodipine can prolong the effects of succinylcholine
Amlodipine ↔ Tocilizumab
Tocilizumab may decrease the blood levels and effects of amlodipine
Amlodipine ↔ Corticotropin
Corticotropin may reduce the effects of amLODIPine in lowering blood pressure. The interaction is most likely to occur when corticotropin is used for more than a week, since prolonged use can cause sodium and water retention
Amlodipine ↔ Flurbiprofen
The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often
Amlodipine ↔ promethazine
Promethazine and amlodipine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Bupropion
Amlodipine and bupropion may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Apomorphine
Apomorphine and amlodipine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption
Amlodipine ↔ Loxapine
Loxapine and amlodipine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Riociguat
Riociguat may add to the blood pressure lowering effects of amlodipine. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Rilonacept
Rilonacept may decrease the blood levels and effects of amlodipine. You may need a dose adjustment if you have been receiving amlodipine and are starting treatment with rilonacept
Amlodipine ↔ Donepezil
Donepezil can occasionally cause excessively slow heart rate and low blood pressure, and using it with amLODIPine may increase that risk
Amlodipine ↔ Pipecuronium
Using pipecuronium together with amlodipine can prolong the effects of pipecuronium. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of amlodipine. You may need a dose adjustment or special test if you use both medications
Amlodipine ↔ Alfentanil
Amlodipine and alfentanil may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Selegiline
Selegiline and amlodipine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Avanafil
Avanafil can add to the blood pressure-lowering effect of amlodipine. Contact your doctor if you experience signs and symptoms of low blood pressure such as dizziness, lightheadedness, fainting, flushing, headache, or a rapid pulse or heart rate
Amlodipine ↔ Calcium carbonate
Using amlodipine together with calcium carbonate can decrease the effects of amlodipine. Talk with your doctor before using amLODIPine and calcium carbonate together
Amlodipine ↔ Opium
Amlodipine and opium may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Bexarotene
Bexarotene may reduce the blood levels and effects of amlodipine
Amlodipine ↔ Bisoprolol
Bisoprolol and amlodipine may have additive effects in lowering your blood pressure and heart rate
Amlodipine ↔ Brexpiprazole
Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking activity. Orthostatic hypotension and syncope associated with vasodilation may occur, particularly during initial dosing and/or parenteral administration of the phenothiazine or neuroleptic
Amlodipine ↔ Bromfenac
The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often
Amlodipine ↔ Sotalol
Sotalol and amlodipine may have additive effects in lowering your blood pressure and heart rate. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heartbeat
Amlodipine ↔ Nebivolol
Nebivolol and amlodipine may have additive effects in lowering your blood pressure and heart rate. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heartbeat
Amlodipine ↔ Cabergoline
Amlodipine and cabergoline may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Amlodipine ↔ Calcium gluconate
Using amlodipine together with calcium gluconate can decrease the effects of amlodipine. Talk with your doctor before using amlodipine and calcium gluconate together
Amlodipine ↔ verapamil
Verapamil may increase the blood levels of amlodipine. You may be more likely to experience serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure
Amlodipine ↔ Cisatracurium
Using cisatracurium together with amlodipine can prolong the effects of cisatracurium. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of amlodipine
Amlodipine ↔ Indomethacin
Before using indomethacin, tell your doctor if you also use amlodipine. The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often
Amlodipine ↔ Nitroglycerin
Using nitroglycerin together with amLODIPine can lower your blood pressure
Amlodipine ↔ Dapagliflozin
Dapagliflozin may cause salt and water loss, which may increase the risk of dehydration and low blood pressure when used with amLODIPine or similar medications. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Food interaction of Amlodipine
Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise. Grapefruit can increase the amount of this medication in your bloodstream
Disease interaction of Amlodipine
Amlodipine ↔ Cardiogenic Shock/Hypotension
Calcium channel blockers (CCBs) should not be used in patients with hypotension (systolic pressure < 90 mm Hg) or cardiogenic shock. Due to potential negative inotropic and peripheral vasodilating effects, the use of CCBs may further depress cardiac output and blood pressure, which can be detrimental in these patients
Amlodipine ↔ Coronary Artery Disease
Increased frequency, duration, and/or severity of angina, as well as acute myocardial infarction, have rarely developed during initiation or dosage increase of calcium channel blockers (CCBs), particularly in patients with severe obstructive coronary artery disease and those treated with immediate-release formulations. The mechanism of this effect is not established. Therapy with CCBs should be administered cautiously in patients with significant coronary artery disease
Amlodipine ↔ Liver Disease
Calcium channel blockers (CCBs) are extensively metabolized by the liver. The half-lives of CCBs may be prolonged substantially in patients with severe hepatic impairment, with the potential for significant drug accumulation. In addition, the use of some CCBs has been associated with elevations in serum transaminases, both with and without concomitant elevations in alkaline phosphatase and bilirubin. Therapy with CCBs should be administered cautiously and often at reduced dosages in patients with significantly impaired hepatic function
Amlodipine ↔ CHF/AMI
Congestive heart failure (CHF), worsening of CHF, and pulmonary edema have occurred in some patients treated with a CCB, primarily verapamil. Some CCBs have also caused mild to moderate peripheral edema due to localized vasodilation of dependent arterioles and small blood vessels, which can be confused with the effects of increasing left ventricular dysfunction