Drug Interactions of Captopril
Captopril ↔ Spironolactone
Using captopril together with spironolactone may increase the levels of potassium in your blood (hyperkalemia), especially if you are dehydrated or have kidney disease, diabetes, heart failure, or if you are an older adult. Hyperkalemia can cause symptoms such as weakness, confusion, numbness or tingling, and uneven heartbeats
Captopril ↔ Aliskiren
Using aliskiren together with captopril may increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia
Captopril ↔ Potassium bicarbonate
Combining these medications may significantly increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia
Captopril ↔ Allopurinol
Talk to your doctor before using allopurinol together with captopril. Combining these medications may increase the risk of severe allergic reactions and infections. You should seek immediate medical attention if you develop shortness of breath; throat tightness; swelling of the face, lips, or tongue; itching; rash; fever; and/or muscle pain or weakness
Captopril ↔ Potassium iodide
Talk to your doctor before using captopril together with potassium iodide. Combining these medications may significantly increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while using these medications if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure
Captopril ↔ Phenobarbital
Captopril and Phenobarbital may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Captopril ↔ Parenteral nutrition solution w/electrolytes
Combining these medications may significantly increase potassium levels in the blood
Captopril ↔ Sodium biphosphate
Bowel cleansing with sodium biphosphate can cause kidney failure, in some cases up to several months after the procedure. Although it rarely occurs, the risk is increased in individuals receiving treatment with captopril, especially if they are also elderly or frail
Captopril ↔ Phenyl salicylate
Talk to your doctor before using captopril together with phenyl salicylate. Combining these medications may reduce the effects of captopril in lowering blood pressure. In addition, these medications may affect your kidney function, especially when they are used together frequently or chronically
Captopril ↔ Irbesartan
Using captopril together with irbesartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and a condition called hyperkalemia (high blood potassium). In severe cases, hyperkalemia can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest
Captopril ↔ Iron dextran
Medications like captopril may occasionally increase the side effects of iron dextran such as allergic reactions, low blood pressure, lightheadedness, fever, flushing, chest pain, back pain, rash, itching, nausea, vomiting, diarrhea, and abdominal pain. Allergic reactions to iron dextran may be serious and potentially life-threatening
Captopril ↔ Timothy grass pollen allergen extract
Using timothy grass pollen allergen extract together with captopril may not be advisable. Treatment with captopril may increase the severity of allergic reactions that can sometimes occur during immunotherapy with timothy grass pollen allergen extract
Captopril ↔ Mipomersen
Mipomersen may cause liver problems, and using it with other medications that can also affect the liver such as captopril may increase that risk
Captopril ↔ Leflunomide
Leflunomide may cause liver problems, and using it with other medications that can also affect the liver such as captopril may increase that risk
Captopril ↔ Tizanidine
Tizanidine and captopril may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate
Food Interactions of Captopril
It is recommended that if you are taking captopril you should be advised to avoid moderately high or high potassium dietary intake. This can cause high levels of potassium in your blood. Do not use salt substitutes or potassium supplements while taking captopril
Disease Interactions of Captopril
Captopril ↔ Angioedema
Patients with a history of angioedema unrelated to ACE inhibitors may be at increased risk of angioedema while receiving an ACE inhibitor. Patients should be advised to immediately report any signs or symptoms suggestive of angioedema (swelling of face, extremities, eyes, lips, or tongue, or difficulty swallowing or breathing) and to stop taking the medication until otherwise directed by their physician
Captopril ↔ Bone Marrow Suppression
ACE inhibitors may cause bone marrow suppression, rarely in uncomplicated individuals but more frequently in patients with renal impairment, especially if they also have a collagen-vascular disease such as systemic lupus erythematosus or scleroderma. Neutropenia, agranulocytosis, aplastic anemia, hemolytic anemia, eosinophilia and thrombocytopenia have been reported, mostly with captopril. Therapy with ACE inhibitors should be administered cautiously in patients with preexisting blood dyscrasias or complications that may increase the risk of bone marrow depression during ACE inhibitor therapy. Monitoring of blood counts, particularly white blood cells, should be considered
Captopril ↔ CHF
Symptomatic and sometimes excessive hypotension can occur in susceptible individuals, particularly during the initiation of treatment, which may compromise renal and myocardial perfusion. In patients with severe congestive heart failure (CHF), treatment with ACE inhibitors may be associated with oliguria and/or progressive azotemia and, rarely, renal failure, myocardial ischemia and death
Captopril ↔ Hemodialysis
Anaphylactoid reactions have been reported in patients undergoing hemodialysis with high-flux polyacrylonitrile membranes and treated concomitantly with an ACE inhibitor. The frequency and mechanism of this interaction have not been established, and it is not known whether the interaction occurs with other membrane types. Therapy with ACE inhibitors should be administered cautiously in patients requiring hemodialysis
Captopril ↔ Hyperkalemia
In patients with hyperkalemia especially that associated with impaired renal function or congestive heart failure ACE inhibitors may further raise serum potassium levels. Therapy with ACE inhibitors should be administered cautiously in patients with or predisposed to hyperkalemia, and serum potassium levels should be carefully monitored
Captopril ↔ Hypotension
ACE inhibitors can cause symptomatic hypotension, most often during the initiation of therapy and in patients who are volume- and/or sodium-depleted or treated for congestive heart failure (CHF). Therapy with ACE inhibitors should be administered cautiously in such patients and in those predisposed to hypovolemic or hyponatremic states (e.g., patients on diuretic therapy, especially if it was recently instituted; those on dietary salt restriction; those with severe or prolonged diarrhea or vomiting; and renal dialysis patients). Volume and/or sodium depletion should be corrected prior to initiating therapy with ACE inhibitors
Captopril ↔ Renal Dysfunction
With the exception of fosinopril, ACE inhibitors (and/or their active metabolites in some cases) are primarily eliminated by the kidney and may accumulate in patients with renal impairment. ACE inhibitors can also worsen renal function in some patients by blocking the effect of angiotensin II-mediated efferent arteriolar vasoconstriction, thereby decreasing glomerular filtration. Therapy with ACE inhibitors should be administered cautiously in patients with preexisting renal dysfunction