Sulfamethoxazole / trimethoprim

فبراير 7, 2016

Sulfamethoxazole / trimethoprim↔ Paclitaxel

Trimethoprim may increase the blood levels of Paclitaxel protein-bound. This can increase the risk of side effects such as nausea, diarrhea, hair loss, muscle pain or weakness, nerve damage, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts

Sulfamethoxazole ↔ ritonavir

The following interaction applies only if you are taking ritonavir products (e.G., Norvir, Kaletra) in a solution formulation: Ritonavir-containing oral solutions are formulated with alcohol. In rare cases, sulfamethoxazole may affect the breakdown of alcohol leading to what is termed a “disulfiram reaction.” This condition produces unpleasant side effects such as flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain

Sulfamethoxazole / trimethoprim↔ quinapril

Using trimethoprim together with quinapril may increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest

Sulfamethoxazole / trimethoprim↔ Acetohexamide

Sulfamethoxazole can increase the effects of Acetohexamide and cause your blood sugar levels to get too low. Symptoms of low blood sugar include headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, and fast or pounding heartbeats

Sulfamethoxazole ↔ brentuximab

Brentuximab vedotin may cause liver problems, and using it with other medications that can also affect the liver such as sulfamethoxazole may increase that risk

Sulfamethoxazole / trimethoprim↔ insulin

Using sulfamethoxazole together with insulin or certain other diabetes medications may increase the risk of hypoglycemia

Sulfamethoxazole / trimethoprim↔ ethanol

Ask your doctor before using trimethoprim together with ethanol. Do not drink alcohol while you are taking trimethoprim. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting

Sulfamethoxazole / trimethoprim↔ sodium nitrite

Sodium nitrite can cause a condition called methemoglobinemia that reduces the oxygen-carrying capacity of the blood to different organs, and combining the medication with sulfamethoxazole may increase the risk

Sulfamethoxazole / trimethoprim↔ anisindione

Using anisindione together with sulfamethoxazole may increase the risk of bleeding, especially if you are elderly or have kidney or liver impairment

Sulfamethoxazole / trimethoprim↔ of ethinyl estradiol

Antibiotics such as sulfamethoxazole may reduce the effects of ethinyl estradiol in some women. If you are using ethinyl estradiol for birth control, you may be at increased risk for pregnancy or breakthrough bleeding

Sulfamethoxazole / trimethoprim↔ methenamine

Using methenamine together with sulfamethoxazole is not recommended. Combining these medications may cause crystals to form in the urine

Sulfamethoxazole / trimethoprim↔ clozapine

CONTRAINDICATED: The use of clozapine with other agents that can cause neutropenia or agranulocytosis may increase the risk and/or severity of hematologic toxicity

Sulfamethoxazole / trimethoprim↔ warfarin

Using warfarin together with sulfamethoxazole may increase the risk of bleeding’especially if you are elderly or have kidney or liver impairment

Sulfamethoxazole/ trimethoprim↔ cyclosporine


Using cyclosporine and sulfamethoxazole together can add to the risk of organ rejection associated with low cyclosporine levels

Using trimethoprim together with cyclosporine may decrease the effects of cyclosporine

Sulfamethoxazole/ trimethoprim↔ prilocaine

Prilocaine topical can cause a condition called methemoglobinemia that reduces the oxygen-carrying capacity of the blood to different organs and combining the medication with sulfamethoxazole may increase the risk

Sulfamethoxazole/ trimethoprim↔ methotrexate

Ask your doctor before using methotrexate and sulfamethoxazole. This can increase the methotrexate levels in your body

Ask your doctor before using methotrexate and trimethoprim, this can cause suppression of bone marrow activity, resulting in reduction in the number of platelets, red blood cells and white blood cells

sulfamethoxazole  / trimethoprim disease interaction

Sulfamethoxazole/trimethoprim ↔ Hematologic Toxicity

The use of sulfonamides has been associated with hematologic toxicity, including methemoglobinemia, sulfhemoglobinemia, leukopenia, granulocytopenia, eosinophilia, hemolytic anemia, aplastic anemia, purpura, clotting disorder, thrombocytopenia, hypofibrinogenemia, and hypoprothrombinemia

Sulfamethoxazole/trimethoprim↔ Hypersensitivity Reactions

The use of sulfonamides is associated with large increases in the risk of Stevens-Johnson syndrome, toxic epidermal necrolysis and other serious dermatologic reactions

Sulfamethoxazole/trimethoprim↔ Liver Disease

Hepatotoxicity, including jaundice, diffuse hepatocellular necrosis, hypersensitivity hepatitis and hepatic failure, has rarely been reported in patients receiving sulfonamides

Sulfamethoxazole/trimethoprim↔ Porphyria

The use of sulfonamides is contraindicated in patients with porphyria, since  these drugs can precipitate an acute attack

Sulfamethoxazole/trimethoprim↔ Renal Dysfunction

Sulfonamides and their metabolites are eliminated by the kidney. Patients with renal impairment may be at greater risk for adverse effects from sulfonamides due to decreased drug clearance

Sulfamethoxazole/trimethoprim↔ Folate Deficiency

The use of trimethoprim is contraindicated in patients with documented megaloblastic anemia due to folate deficiency. Trimethoprim inhibits dihydrofolate reductase, an enzyme necessary in the synthesis of tetrahydrofolic acid

Sulfamethoxazole/trimethoprim↔ Colitis

Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening

Sulfamethoxazole/trimethoprim↔ Crystalluria

Crystalluria can occur during sulfonamide therapy due to precipitation of the sulfonamide and/or its N4-acetyl metabolite in the urinary tract

Sulfamethoxazole/trimethoprim↔ Hemodialysis

The sulfonamides, sulfadiazine, sulfamethoxazole, and sulfisoxazole, are partially removed by hemodialysis and should be administered after dialysis

Sulfamethoxazole/trimethoprim↔ Urinary Obstruction

Sulfonamides are excreted and concentrated in the urine. Therapy with sulfonamides should be administered cautiously in patients with urinary obstruction

Trimethoprim (Includes Sulfamethoxazole/trimethoprim) ↔ Renal Dysfunction

Trimethoprim is primarily eliminated by the kidney. The serum concentration of trimethoprim may be increased and the half-life prolonged in patients with impaired renal function



Posted in التفاعلات الدوائية by Nirvana Youssef