Sulfamethoxazole / trimethoprim↔ Paclitaxel
Trimethoprim may increase the blood levels of Paclitaxel protein-bound. This can increase the risk of side effects such as nausea, diarrhea, hair loss, muscle pain or weakness, nerve damage, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts
Sulfamethoxazole ↔ ritonavir
The following interaction applies only if you are taking ritonavir products (e.G., Norvir, Kaletra) in a solution formulation: Ritonavir-containing oral solutions are formulated with alcohol. In rare cases, sulfamethoxazole may affect the breakdown of alcohol leading to what is termed a “disulfiram reaction.” This condition produces unpleasant side effects such as flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain
Sulfamethoxazole / trimethoprim↔ quinapril
Using trimethoprim together with quinapril may increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest
Sulfamethoxazole / trimethoprim↔ Acetohexamide
Sulfamethoxazole can increase the effects of Acetohexamide and cause your blood sugar levels to get too low. Symptoms of low blood sugar include headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, and fast or pounding heartbeats
Sulfamethoxazole ↔ brentuximab
Brentuximab vedotin may cause liver problems, and using it with other medications that can also affect the liver such as sulfamethoxazole may increase that risk
Sulfamethoxazole / trimethoprim↔ insulin
Using sulfamethoxazole together with insulin or certain other diabetes medications may increase the risk of hypoglycemia
Sulfamethoxazole / trimethoprim↔ ethanol
Ask your doctor before using trimethoprim together with ethanol. Do not drink alcohol while you are taking trimethoprim. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting
Sulfamethoxazole / trimethoprim↔ sodium nitrite
Sodium nitrite can cause a condition called methemoglobinemia that reduces the oxygen-carrying capacity of the blood to different organs, and combining the medication with sulfamethoxazole may increase the risk
Sulfamethoxazole / trimethoprim↔ anisindione
Using anisindione together with sulfamethoxazole may increase the risk of bleeding, especially if you are elderly or have kidney or liver impairment
Sulfamethoxazole / trimethoprim↔ of ethinyl estradiol
Antibiotics such as sulfamethoxazole may reduce the effects of ethinyl estradiol in some women. If you are using ethinyl estradiol for birth control, you may be at increased risk for pregnancy or breakthrough bleeding
Sulfamethoxazole / trimethoprim↔ methenamine
Using methenamine together with sulfamethoxazole is not recommended. Combining these medications may cause crystals to form in the urine
Sulfamethoxazole / trimethoprim↔ clozapine
CONTRAINDICATED: The use of clozapine with other agents that can cause neutropenia or agranulocytosis may increase the risk and/or severity of hematologic toxicity
Sulfamethoxazole / trimethoprim↔ warfarin
Using warfarin together with sulfamethoxazole may increase the risk of bleeding’especially if you are elderly or have kidney or liver impairment
Sulfamethoxazole/ trimethoprim↔ cyclosporine
Using cyclosporine and sulfamethoxazole together can add to the risk of organ rejection associated with low cyclosporine levels
Using trimethoprim together with cyclosporine may decrease the effects of cyclosporine
Sulfamethoxazole/ trimethoprim↔ prilocaine
Prilocaine topical can cause a condition called methemoglobinemia that reduces the oxygen-carrying capacity of the blood to different organs and combining the medication with sulfamethoxazole may increase the risk
Sulfamethoxazole/ trimethoprim↔ methotrexate
Ask your doctor before using methotrexate and sulfamethoxazole. This can increase the methotrexate levels in your body
Ask your doctor before using methotrexate and trimethoprim, this can cause suppression of bone marrow activity, resulting in reduction in the number of platelets, red blood cells and white blood cells
sulfamethoxazole / trimethoprim disease interaction
Sulfamethoxazole/trimethoprim ↔ Hematologic Toxicity
The use of sulfonamides has been associated with hematologic toxicity, including methemoglobinemia, sulfhemoglobinemia, leukopenia, granulocytopenia, eosinophilia, hemolytic anemia, aplastic anemia, purpura, clotting disorder, thrombocytopenia, hypofibrinogenemia, and hypoprothrombinemia
Sulfamethoxazole/trimethoprim↔ Hypersensitivity Reactions
The use of sulfonamides is associated with large increases in the risk of Stevens-Johnson syndrome, toxic epidermal necrolysis and other serious dermatologic reactions
Sulfamethoxazole/trimethoprim↔ Liver Disease
Hepatotoxicity, including jaundice, diffuse hepatocellular necrosis, hypersensitivity hepatitis and hepatic failure, has rarely been reported in patients receiving sulfonamides
Sulfamethoxazole/trimethoprim↔ Porphyria
The use of sulfonamides is contraindicated in patients with porphyria, since these drugs can precipitate an acute attack
Sulfamethoxazole/trimethoprim↔ Renal Dysfunction
Sulfonamides and their metabolites are eliminated by the kidney. Patients with renal impairment may be at greater risk for adverse effects from sulfonamides due to decreased drug clearance
Sulfamethoxazole/trimethoprim↔ Folate Deficiency
The use of trimethoprim is contraindicated in patients with documented megaloblastic anemia due to folate deficiency. Trimethoprim inhibits dihydrofolate reductase, an enzyme necessary in the synthesis of tetrahydrofolic acid
Sulfamethoxazole/trimethoprim↔ Colitis
Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening
Sulfamethoxazole/trimethoprim↔ Crystalluria
Crystalluria can occur during sulfonamide therapy due to precipitation of the sulfonamide and/or its N4-acetyl metabolite in the urinary tract
Sulfamethoxazole/trimethoprim↔ Hemodialysis
The sulfonamides, sulfadiazine, sulfamethoxazole, and sulfisoxazole, are partially removed by hemodialysis and should be administered after dialysis
Sulfamethoxazole/trimethoprim↔ Urinary Obstruction
Sulfonamides are excreted and concentrated in the urine. Therapy with sulfonamides should be administered cautiously in patients with urinary obstruction
Trimethoprim (Includes Sulfamethoxazole/trimethoprim) ↔ Renal Dysfunction
Trimethoprim is primarily eliminated by the kidney. The serum concentration of trimethoprim may be increased and the half-life prolonged in patients with impaired renal function