Drug-drug interaction of Vancomycin

Vancomycin ↔ Tenofovir

Tenofovir may cause kidney problems, and combining it with other medications that can also affect the kidney such as vancomycin may increase that risk.

Vancomycin ↔ Adefovir

Adefovir may cause kidney problems, and combining it with other medications that can also affect the kidney such as vancomycin may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Vancomycin ↔ Tacrolimus

Vancomycin may cause kidney problems, and combining it with other medications that can also affect the kidney such as tacrolimus may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Vancomycin ↔ Botulism immune globulin

Botulism immune globulin may cause kidney problems, and combining it with other medications that can also affect the kidney such as vancomycin may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Vancomycin ↔ Cytomegalovirus immune globulin

Cytomegalovirus immune globulin may cause kidney problems, and combining it with other medications that can also affect the kidney such as vancomycin may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Vancomycin ↔ Deferasirox

Deferasirox may cause kidney problems, and combining it with other medications that can also affect the kidney such as vancomycin may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Vancomycin ↔ Metformin

Using metFORMIN together with vancomycin may increase the effects of metFORMIN. You should monitor your blood glucose and contact your doctor if you experience weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. You may need a dose adjustment and you may need to check your blood sugar more often to safely use both medications.

Vancomycin ↔ Amikacin

Using amikacin together with vancomycin may be harmful to your kidneys and cause nerve damage leading to hearing loss.

Vancomycin ↔ Amphotericin b

Using amphotericin B together with vancomycin can increase the risk of kidney and inner ear damage. These effects may be more likely to occur in older adults or those with preexisting kidney problems or dehydration, or when high dosages of one or both medications are used.

Vancomycin ↔ Kanamycin or Gentamicin

Using vancomycin together with kanamycin or Gentamicin may be harmful to your kidneys and cause nerve damage leading to hearing loss.

Vancomycin ↔Cholestyramine and colestipol

The following interaction applies only if you are receiving vancomycin orally: cholestyramine may interfere with the absorption of vancomycin when these medications are taken at the same time. This may reduce the blood levels and effects of vancomycin. To prevent or minimize the interaction, vancomycin should be taken at least 1 hour before or 4 to 6 hours after the cholestyramine dose.

Drug-food interaction of Vancomycin

There are no restrictions on food, drink, or activities while taking vancomycin unless your doctor tells you otherwise.

Drug-disease interaction

Vancomycin ↔ Ototoxicity

Intravenous use of vancomycin may cause damage to the auditory branch of the eighth cranial nerve. Permanent hearing loss has been reported. Tinnitus sometimes precedes the onset of deafness, which may progress despite withdrawal of the drug. Therapy with vancomycin, particularly if prolonged (> 10 days), should be administered cautiously in patients with preexisting auditory impairment or tinnitus, since it may delay the recognition or confound the diagnosis of a drug-induced ototoxic effect.

Vancomycin ↔ Renal Dysfunction

Therapy with vancomycin should be administered cautiously at reduced dosages in patients with renal impairment, since they may be at increased risk for oto- and nephrotoxicity due to drug accumulation.

Vancomycin ↔ Colitis

Antibiotic therapy can alter the normal flora of the colon and permit overgrowth of Clostridium difficile, whose toxin is believed to be a primary cause of antibiotic-associated colitis. Therapy with broad-spectrum antibiotics and other agents with significant antibacterial activity should be administered cautiously in patients with a history of gastrointestinal diseases, particularly colitis.

Vancomycin ↔ Neutropenia

Reversible neutropenia has been reported occasionally with intravenous use of vancomycin, usually starting one week or more after initiation of therapy or after a total dosage of more than 25 g. Patients with preexisting neutropenia should be monitored closely during vancomycin therapy for further decreases in leukocyte counts, and therapy discontinued if appropriate.

Oral Vancomycin ↔ GI Inflammation

Therapy with oral vancomycin should be administered cautiously in patients with inflammatory or ulcerative gastrointestinal diseases because of the potential for enhanced absorption of the drug.